Kara L. Vander Linden, Glaser Center for Grounded Theory, Institute for Research and Theory Methodologies, United States Patrick A. Palmieri, South American Center for Qualitative Research, Universidad Norbert Wiener, Perú; College of Graduate Health Studies, A.T. Still University, United States Abstract The research study protocol is a roadmap for conducting research systematically, efficiently, and ethically. While protocols have standard components, a classic grounded theory protocol differs in its methods, including processes and procedures, because of the uniqueness of the methodology. A classic grounded theory protocol commonly contains the following: (1) introduction to the topic; (2) purpose of the study with the research question; (3) detailed description of the research methods, including data collection and analysis; and (4) procedures to demonstrate the ethical conduct of human participant research. Based on a review of grounded theory methodological literature, the current article describes an approach for developing a research protocol that maintains grounded theory research integrity while adhering to institutional and funding requirements. A properly written study protocol is essential for maintaining methodological fidelity, avoiding method slurring, and unintended remodeling in classic grounded theory. Keywords: Classic Grounded Theory, Study Protocol, Theoretical Sampling, Data Collection, Constant Comparative Method of Analysis, Theory Development. The rapid advancement of qualitative research across the disciplines, described as the “crest of a wave” (Morse, 1994, p. 139), resulted in methodological approaches being considered a unified field for the purpose of critical appraisal (Dixon-Woods et al., 2004). For this reason, aspects of qualitative research, including trustworthiness and rigor, continue to be debated among scholars because of the epistemological differences of the methodologies (Garside, 2014). Even though some methodologists disagree, grounded theory is commonly classified as a qualitative methodology, but this does not mean that a grounded theory uses the same processes and procedures as other methodologies. Since each methodology has procedures to demonstrate rigor and techniques to establish trustworthiness (Vander Linden & Palmieri, 2021), a comprehensive research proposal and the briefer research study protocol are essential to identify, describe, explain, and justify the plan for conducting research using grounded theory. Qualitative research designs are emergent in nature. As such, research is conducted by design rather than designed while being conducted (Sandelowski et al., 1989). The design is prospectively described in the research proposal, a comprehensive document to justify a thesis or dissertation, support a planned research study, and obtain funding for research (Lusk, 2004). Research proposals across research designs are developed with similar sections including the cover page, abstract, introduction, review of the literature, research problem and research questions, research purpose and objectives, research paradigm, research design, research method, ethical considerations, dissemination plan, budget, and supporting appendices (Klopper, 2008). Since “process is outcome” (Sandelowski & Barroso, 2003, p. 781) in methodological studies, the comprehensive research proposal is distilled into a research study protocol that provides a clear, concise, and detailed plan to carry out the study. A good quality research study protocol should be able to justify the research, answer the research question, achieve the study objectives, provide enough details about the methods to replicate the study, and demonstrate the ethical treatment of human participants. A research study protocol, often referred to as the study protocol, is the roadmap for researchers to conduct their study systematically, efficiently, and ethically. A classic grounded theory protocol differs in some areas because of its unique aspects of the methodology (Xie, 2009). Despite variations in content caused by institutional requirements, a classic grounded theory protocol commonly contains the following areas: (1) introduction to...